Table 1.
Treatment and assessment regimes for patients in Group I (active treatment). Clindamycin infusions were given in 250 mL normal saline over one hour. Patients in Group II (placebo) received placebo infusions of normal saline and placebo tablets according to the same regime; they had the same assessment regime. bd: taken twice a day (morning and evening). × 3/wk: three times per week. Assessments: C, clinical; L, laboratory.
| Time | Clindamycin infusion | Tetracycline | Assessment | |
|---|---|---|---|---|
| C | L | |||
| Day 1 | 300 mg | 250 mg bd | + | + |
| Day 2 | 300 mg | none | ||
| Day 3 | 600 mg | 250 mg bd | ||
| Day 4 | 600 mg | none | ||
| Day 5 | 900 mg | 250 mg bd | ||
| Weeks 2–4 | 900 mg per week | 250 mg bd × 3/wk | ||
| Weeks 5–8 | 900 mg fortnightly | 250 mg bd × 3/wk | ||
| At week 9 | + | + | ||
| Weeks 9–16 | 900 mg fortnightly | 250 mg bd × 3/wk | ||
| At week 17 | + | + | ||
| Weeks 17–24 | 900 mg fortnightly | 250 mg bd × 3/wk | ||
| At week 25 | + | + | ||