Table 2.
Percent worm reduction (protection) in jirds challenged with 100 B. malayi L3
| Vaccination groups | Percent protection |
|---|---|
| pVAXBmVAL-1 DNA monovalent homologous | 50 ± 3.7% |
| rBmVAL-1 protein monovalent homologous | 40.0 ± 3.1% |
| pVAXBmVAL-1 DNA plus rBmVAL-1 monovalent heterologous | 52.4 ± 2.5% |
| pVAXBmALT-2 DNA monovalent homologous | 58.3 ± 2.1% |
| rBmALT-2 protein monovalent homologous | 72.0 ± 5.5% |
| pVAXBmALT-2 DNA plus rBmALT-2 monovalent heterologous | 78.5 ± 3.2% |
| pVAXBmVAL-1/ALT-2 DNA multivalent homologous | 77.1 ± 2.0% |
| rBmVAL-1/rBmALT-2 protein multivalent homologous | 79.9 ± 3.5% |
| pVAXBmVAL-1/BmALT-2 DNA plus rBmVAL-1/rBmALT-2 multivalent heterologous | 85.0 ± 1.4% |
| pVAX + Alum control | 0% |
Note: Significance P < 0.01 compared with control. Values were calculated as the percent reduction in worm establishment compared with control jirds that had a total of 39 ± 7 worms established.