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Illustration of how high K fed BKβ1-KO can develop of Na, Cl and fluid retention. On high dietary K intake, the absence of BKβ1 in the CNT results in relative basolateral K recycling instead of its secretory role. The elevated K stimulates aldosterone production from the adrenals which have enhanced sensitivity to K in BKβ1-KO. The increased plasma aldosterone stimulates Na and Cl reabsorption instead of an exchange of K for Na.
