Table 2.
The effect of 100 uM clotrimazole, 50 uM glibenclamide, and 7 uM cromakalim on the tension and rate of smooth muscle contraction expressed as grams tension in the in vitro rabbit ileum incubated in Krebs-Ringer solution. Results are expressed as means ± standard error of the mean with the number of observations in parenthesis. Statistical significance (a P < .001; b P < .02; c P < .05) for comparison of parameters prior to and after drug administration.
| Basal tension (gms) | Peak tension (gms) | Average tension (gms) | Tension amplitude (gms) | Rate of contraction (per minute) | |
|---|---|---|---|---|---|
| Pre clotrimazole | 2.51 ± 0.88 (4) | 5.90 ± 0.76 (4) | 3.74 ± 0.53 (6) | 3.39 ± 0.88 (4) | 13.9 ± 1.1 (4) |
| Post clotrimazole | 2.50 ± 0.84 (4) | 4.63 ± 0.55 (4)a | 2.61 ± 0.72 (6)c | 2.18 ± 0.81 (4)a | 13.4 ± 1.5 (4) |
|
| |||||
| Pre glibenclamide | 1.98 ± 0.54 (3) | 6.69 ± 0.79 (3) | 4.34 ± 0.41 (3) | 4.70 ± 1.07 (3) | 14.6 ± 2.4 (3) |
| Post glibenclamide | 3.14 ± 0.57 (3)a | 8.01 ± 2.45 (3) | 5.58 ± 1.51 (3) | 4.87 ± 1.90 (3) | 13.8 ± 2.6 (3) |
|
| |||||
| Pre cromakalim | 1.73 ± 0.62 (3) | 6.50 ± 0.81 (3) | 4.12 ± 0.26 (3) | 5.10 ± 1.33 (3) | 14.5 ± 1.8 (3) |
| Post cromakalim | 1.60 ± 0.64 (3) | 4.37 ± 1.62 (3) | 2.98 ± 1.06 (3) | 2.77 ± 1.25 (3)c | 13.8 ± 2.1 (3) |