Figure 1.
(A) Global H/DX kinetics experiments: calmodulin with no Ca2+(1 mM EGTA) (squares), calmodulin with 2 mM Ca2+ (diamonds), 2:1 melittin:calmodulin with 2 mM Ca2+ (triangles), 2:1 mastoparan:calmodulin with 2 mM Ca2+ (circles) and 2:1 MLCK:calmodulin with 2 mM Ca2+ (open squares). H/DX was conducted over a 60 min time course with 97% D2O, 10 mM HEPES (pH 7.4), 150 mM KCl, and 4–5 µM calmodulin. (B) Results of the fixed-rate kinetic binning model for the four kinetics curves in A.