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. Author manuscript; available in PMC: 2012 Feb 1.
Published in final edited form as: Future Med Chem. 2011 Apr;3(5):623–638. doi: 10.4155/fmc.11.9

Figure 2. Model illustrating the regulation of a target gene by both retinoic acid receptor-related orphan receptors and REV-ERB.

Figure 2

REV-ERB functions as a receptor for heme, which is required for its activity as a repressor. Several sterols have been suggested as ligands for the RORs. In this cartoon, sterols regulate the constitutive activity of the RORs.

ROR: Retinoic acid receptor-related orphan receptor; RORE: ROR response element.