Table 2.
Odds ratios (ORs) and 95% confidence intervals (CIs) for hyper-LDL cholesterolemia by Mt5178 C/A genotype and alcohol consumption
| Frequency | ||||
|---|---|---|---|---|
| Genotype and alcohol consumption | Normal LDL cholesterol (LDL cholesterol < 140 mg/dl) |
Hyper-LDL cholesterolemia (LDL cholesterol ≥ 140 mg/dl) |
OR (95% CI) | Adjusted OR† (95% CI) |
| Mt5178C | ||||
| Non- or ex-drinkers (%) | 28 (63.6) | 16 (36.4) | 1 (reference) | 1 (reference) |
| Occasional drinkers (%) | 58 (69.1) | 26 (30.9) | 0.784 (0.364-1.692) | 0.694 (0.290-1.660) |
| Daily drinkers (%) | 90 (81.1) | 21 (18.9) | 0.408 (0.188-0.888)* | 0.360 (0.153-0.847)* |
| P for trend = 0.015 | P for trend = 0.014 | |||
| Mt5178A | ||||
| Non- or ex-drinkers (%) | 16 (76.2) | 5 (23.8) | 1 (reference) | 1 (reference) |
| Occasional drinkers (%) | 45 (75.0) | 15 (25.0) | 1.067 (0.334-3.409) | 1.190 (0.318-4.447) |
| Daily drinkers (%) | 54 (73.0) | 20 (27.0) | 1.185 (0.384-3.660) | 1.232 (0.361-4.206) |
| P for trend = 0.730 | P for trend = 0.558 | |||
LDL; low-density lipoprotein. †OR adjusted for age, body mass index, habitual smoking, coffee consumption and antihypertensive medication use.
*P < 0.05.