Table I.
Mycobacterial antigens recognized by human CD8+ T cells
| Antigena | Rv numberb | Restrictionc | Epitoped | Sequencee | Frequencyf | Ref |
|---|---|---|---|---|---|---|
| CFP10 | Rv3874 | a) HLA-B14 | a) CFP1085–94 | a) RADEEQQQAL | a) 1/2,100h; LTBIk | (22) |
| b) HLA-B44 | b) CFP102–11 | b) AEMKTDAATL | b) 1/700h; LTBI | |||
| CFP10 | Rv3874 | a) HLA-A*02 | a) CFP1076–85 | a) IRQAGVQYSR | ND | (147) |
| b) HLA-B*35 | b) CFP1071–79 | b) EISTNIRQA | ||||
| ESAT6 | Rv3875 | a) HLA-A2 | a) ESAT682–90 | a) AMASTEGNV | a) 1/50,000h; TB | (19) |
| b) HLA-B52 | b) ESAT669–76 | b) LQNLARTI | b) 1/23,000h; TB | |||
| ESAT6 | Rv3875 | HLA-A68.02 | ESAT621–29 | NVTSIHSLL | 1/2,500h; LTBI | (148) |
| Ag85A | Rv3804c | HLA-A2 | a) Ag85A48–56 | a) GLPVEYLQV | a) 1/3,500g,i; BCG | (108) |
| b) Ag85A242–250 | a) KLIANNTRV | b) 1/3,500g,i; BCG | ||||
| Ag85B | Rv1886c | HLA-A2 | a) Ag85B143–152 | a) FIYAGSLSAL | ND | (109) |
| b) Ag85B126–135 | b) SMAGSSAMIL | |||||
| c) Ag85B199–207 | c) KLVANNTRL | |||||
| d) Ag85B158–166 | d) GMGPSLIGL | |||||
| Ag85B | Rv1886c | HLA-A*0201 | Ag85B15–23 | LMIGTAAAV | ND | (196) |
| Ag85C | Rv0129c | HLA-B*3501 | Ag85C204–212 | WPTIIGLAM | 1/13,700–22,222h; BCG | (110) |
| Ag85ABC | HLA-B*35 | Ag85A110–118 | MPVGGQSSF | ND | (110) | |
| 19 kDa | Rv3763 | HLA-A*0201 | 19 kDa88–97 | VLTDGNPPEV | ND | (18) |
| 19 kDa | Rv3763 | HLA-A*0201 | 19 kDa88–97 | VLTDGNPPEV | 1/123–769g,i | (153) |
| 16 kDa | Rv2031c | HLA-A*0201 | a) 16-kDa21–29 | a) LFAAFPSFA | ~ 1/1000g,j; TB | (156) |
| b) 16-kDa120–128 | b) GILTVSVA | |||||
| SodA | Rv3846 | HLA-A2 | SodA160–168 | DMWEHAFYL | ND | (227) |
| AlaDH | Rv0512 | HLA-A2 | AlaDH160–169 | VLMGGVPGVE | ND | (227) |
| GlnS | Rv2220 | HLA-A2 | GlnS308–316 | GLLHHAPSL | ND | (227) |
| Mtb39 | Rv1196 | HLA-B44 | a) Mtb39144–153 | a) MWAQDAAAMF | ND | (116) |
| b) Mtb39346–355 | b) AAERGPGQML | |||||
| ThyA | Rv2764c | HLA-A*0201 | ThyA30–38 | RLPLVLPAV | ND | (196) |
| PstA1 | Rv0930 | HLA-A*0201 | PstA175–83 | SLYFGGICV | ND | (196) |
| Hbha | Rv0475 | ND | ND | ND | ND | (182) |
a
Common name for antigen.
b
The Rv designation for the mycobacterial protein.
c
The restricting MHC protein and allele, if known.
d
The location of the epitope within protein sequence.
e
The amino acid sequence of the epitope.
f
The frequency of antigen-specific T cells in PBMC unless otherwise stated.
g
The frequency of antigen-specific T cells among CD8+ T cells.
h
Determined using an Elispot assay.
i
Determined by flow cytometric analysis using peptide-loaded class I MHC-tetramers.
j
Determined by flow cytometric analysis using intracellular cytokine staining.
k
Infection status of subjects: LTBI, latent tuberculosis infection; TB, active tuberculosis; BCG, BCG vaccinated.
ND, not determined