Table II.
Mycobacterial antigens recognized by murine CD8+ T cells
Antigena | Rv numberb | Restrictionc | Epitoped | Sequencee | Frequencyf | Tissueg | Ref |
---|---|---|---|---|---|---|---|
CFP10 | Rv3874 | H-2 Kk | CFP1032–39 | VESTAGSL | 1/3i | lung | (126) |
TB10.3 | Rv0288 | H-2 Kd | TB10.320–28 | GYAGTLQSL | 1/3i | lung | (122;126) |
TB10.4 | Rv3019c | TB10.420–28 | |||||
Mtb32 | Rv0125 | H-2 Db | 32C93–102 | GAPINSATAM | 1/13i | lung | (158;159) |
MPT51 | Rv3803c | H-2 Dd | MPT5124–32 | GGPHAVYLL | 1/91j | spleen | (149) |
PstS3 | Rv0928 | H-2 Db | PstS3285–293 | SGVGNDLVL | 1/5650h | spleen | (203) |
MPT64 | Rv1980c | H-2 Db | MPT64190–198 | FAVTNDGVI | 1/6250i,k | spleen | (157) |
Ag85A | Rv3804c | H-2 Kd | Ag85A144–152 | VYAGAMSGL | ND | (122) | |
38 kD | Rv0934 | H-2b | 38225–234 | ALGENGNGGM | ND | (106;111;157) |
Common name for antigen.
The Rv designation for the mycobacterial protein.
The restricting MHC protein, if known; if not, the H-2 haplotype of the mouse strain.
The location of the epitope within protein sequence.
The amino acid sequence of the epitope.
The frequency of antigen-specific T cells among CD8+ T cells.
The tissue used to determine the T cell frequency.
Determined using an Elispot assay
Determined by flow cytometric analysis using peptide-loaded class I MHC-tetramers.
Determined by flow cytometric analysis using intracellular cytokine staining
Mice infected with BCG ND, not done