Table 1.
Top Findings of Candidate Gene Association Studies to Date
| Candidate Gene Association Study |
Source of Subjects |
Numbers of Subjects |
Gene Highlighted |
Best Reported P Values* |
|---|---|---|---|---|
| (Neves-Pereira et al. 2002) | 282 Canadian Caucasian families | 282 BD probands; 564 parent CTLs (triads) | BDNF (rs6265) | 3.9 E(−04) for 3-G allele haplotype TDT |
| (Mundo E 2003) | 288 Canadian families (96.8% Caucasian) | 276 BD probands; 576 parent CTLs (triads) | GRIN1 (rs35655437**) | 7.0 E(−03) for haplotype TDT |
| (Chen et al. 2004) | North American Caucasian families | 139 BD; 113 CTLs | DAOA (G72/G30) (rs1935062) | 4.0 E(−03) for 3 allele haplotype |
| (Van Den Bogaert et al. 2006) | Northern SwedishClinics | 182 BD; 135 MDD; 364 CTLs | TPH2 (rs4131348 BD, rs11178997 MDD) | 4.0 E(−03) for BD 1.0 E(−03) for MDD |
| (Xu et al. 2006) | Canadian (Caucasien) clinics | 178 BD; 268 CTLs | TRPM2 (rs1618355) | 2.3 E(−12) for seven marker haplotype |
| (Palo et al. 2007) | 179 Finnish families | 219 BD probands; 361 parent CTLs | DISC1 (rs821616 and rs1411771) | 2.0 E(−04) for under-transmitted in haplotype TDT |
| (Abou Jamra et al. 2008) | German clinics | 425 BD; 419 CTLs | CD36 (FAT) (rs2637777) | 1.8 E(−05) for five marker haplotype |
| (Xu et al. 2008) | Canadian (Caucasien) clinics | 178 BD; 120 CTLs | NDUFV2 (rs1156044) | 2.0 E(−03) |
Best p values were selected from amongst all reports on each particular gene, regardless of the same or different SNP rs numbers. They are given only in terms of allelic count association (two-tailed, prior to correction for multiple testing). The selection criteria for this table were: (a) only genes investigated in at least two peer-reviewed reports of bipolar disorder, totaling at least 5 independent case-control populations under study, and there had to be at least two more positive than negative reports; (b) the study which was chosen to represent the gene was the one with the best allelic p value regardless of rs numbers.
The report on GRIN1 referred to variant 6608-A/G which may correspond to rs35655437 in intron 11.
Abbreviations: BD (bipolar disorder); CTLs (healthy controls); MDD (major depressive disorder); TDT (transmission disequilibrium test).