TABLE 3.

Final Multivariable Models for Higher Log Transformed Brain Natriuretic Peptide Concentrations^*

	PE (SE)	p Value
Demographics, n=510, model R²=0.04, Adjusted R²=0.04^**
Female gender	0.21 (0.08)	0.01
Older age at enrollment	0.05 (0.01)	<0.01
Pre-Fontan Characteristics, n=466, model R²=0.06, Adjusted R²=0.06^**
Presence of systolic ventricular dysfunction on pre-Fontan echocardiography	0.52 (0.16)	<0.01
Fontan Characteristics, n=510, model R²=0.10, Adjusted R²=0.09,^**
Type of Fontan connection		<0.01
Atriopulmonary	−0.38 (0.30)
Intracardiac lateral tunnel	−0.72 (0.28)
Extracardiac lateral tunnel	−1.01 (0.31)
Extracardiac conduit	−1.18 (0.30)
Other	reference
Post-Fontan Characteristics, n=510, model R²=0.08, Adjusted R²=0.08^**
Greater total number of complications	0.08 (0.03)	<0.01
Post-Fontan thrombosis	0.45 (0.17)	<0.01
Combined Medical History Characteristics, n=468, model R²=0.16, Adjusted R²=0.15^**
Presence of systolic ventricular dysfunction on pre-Fontan echocardiography	0.48 (0.15)	<0.01
Type of Fontan connection		<0.01
Atriopulmonary	−0.37 (0.32)
Intracardiac lateral tunnel	−0.58 (0.30)
Extracardiac lateral tunnel	−0.85 (0.33)
Extracardiac conduit	−1.07 (0.32)
Other	reference
Greater number of post-Fontan complications during follow-up	0.11 (0.03)	<0.01
Post-Fontan thrombosis during follow-up	0.41 (0.17)	0.02
Parent-Completed CHQ Summary Scores, n=483, model R²=0.05, Adjusted R²=0.04^**
Lower Physical Functioning Summary score	0.01 (0.004)	0.02
Parent-Completed CHQ Domain Scores, n=503, model R²=0.06, Adjusted R²=0.06^**
Lower Physical Functioning Domain score	0.007 (0.002)	<0.01
Parent-Completed CHQ Health Conditions, n=494, model R²=0.07, Adjusted R²=0.06^**
Orthopedic / bone / joint problems	0.41 (0.13)	<0.01
Allergy / sinus problems	0.26 (0.11)	0.02
Cardiopulmonary Exercise Testing, n=135, model R²=0.17^, Adjusted R²=0.14*^
Lower chronotropic index	1.56 (0.60)	0.01
Echocardiography^†, n=389, model R²=0.15, Adjusted R²=0.14^***
Lower AW peak late diastolic velocity (m/sec)	1.40 (0.41)	<0.01
Longer duration of AV late diastohc inflow (msec)	0.01 (0.002)	<0.01
Magnetic Resonance Imaging, n=153, model R²=0.33, Adjusted R²=0.31^***
Ventricular mass index > 95^th percentile	1.87 (0.28)	<0.01

after logarithmic transformation (with the natural base)

^**

adjusted for age at enrollment and gender

^***

adjusted for age at enrollment and gender, and type of Fontan connection

^†

Missing echocardiographic variable values were imputed from the subset with mass-volume data

AVV, atrioventricular valve; CHQ, Child Health Questionnaire; PE, parameter estimate; SE, standard error