Table 5. Multiple-SNP epistatic analyses.
odds ratios and 95% confident intervals (95% CI), for the analyses including all cases (the top) and only Caucasian cases (the bottom). Only effects with p value < 0.05 are displayed. The term X1:X2 represents interaction between X1 and X2.
| a. Cockerham model | |||||
|---|---|---|---|---|---|
| SNP | additive | dominance | additive:additive | additive:dominance | dominance:additive |
| OR (95% CI) | OR (95% CI) | OR (95% CI) | OR (95% CI) | OR (95% CI) | |
| rs12733285 | 0.643** (0.478–0.864) 0.672** (0.497–0.908) |
||||
| rs7539542 | 1.657** (1.139–2.410) 1.543* (1.011–2.355) |
||||
| rs266729 | 0.536*** (0.375–0.767) 0.546*** (0.380–0.784) |
||||
| rs822396 | 0.386*** (0.228–0.654) 0.454** (0.262–0.788) |
||||
| rs1342387:r s266729 | 2.091*** (1.368–3.197) 2.038*** (1.321–3.144) |
||||
| rs10920531: rs266729 | 1.969** (1.249–3.105) 1.971** (1.241–3.132) |
||||
| rs2241766:r s7539542 | 0.532*(0.532–0.876) 0.542* (0.325–0.905) |
||||
| rs1342387:r s1501299 | 1.593**(1.157–2.191) 1.550**(1.121–2.143) |
||||
| b. Codominant model | ||||
|---|---|---|---|---|
| SNP | additive | dominance | additive:dominance | dominance:additiv |
| OR (95% CI) | OR (95% CI) | OR (95% CI) | OR (95% CI) | |
| rs7539542 | 1.732**(1.192–2.518) 1.702**(1.165–2.487) |
|||
| rs10920531 | 0.634*(0.424–0.948) 0.642* (0.427–0.967) |
|||
| rs266729 | 0.435* (0.212–0.792) 0.485* (0.237–0.995) |
0.578**(0.421–0.792) 0.609** (0.442–0.840) |
||
| rs822396 | 0.561**(0.377–0.832) 0.577** (0.387–0.860) |
|||
| rs1501299 | 0.574*(0.333–0.990) 0.591*(0.340–1.026) |
0.597*(0.437–0.817) 0.585*(0.425–0.806) |
||
| rs10920531:rs2 66729 | 3.686*(1.281–10.608) 3.468* (1.200–10.020) |
|||
| rs12733285:rs2 66729 | 0.224*(0.084–0.597) 0.235**(0.088–0.627) |
|||
*
≤0.05;
**
≤0.01;
***
≤0.001