Table 4.
Published studies of FABP2 and A54T
| Subjects/description | Genetic marker | Result* | Phenotype | Ref |
| A. Sib-pair study | ||||
| Non-diabetic Pima Indians | [4] | |||
| MNS red cell antigen | + | maximal insulin-stimulated glucose uptake | ||
| + | insulin action index | |||
| - | fasting insulin | |||
| Non-diabetic Pima Indians | [5] | |||
| ANX5 | + | maximal insulin-stimulated glucose uptake | ||
| FABP2 | + | maximal insulin-stimulated glucose uptake | ||
| + | fasting insulin | |||
| Non-diabetic Mexican Americans | [15] | |||
| FABP2 | + | 2-h post challenge insulin levels | ||
| Pondicherian Tamil Indians | [16] | |||
| A54T | - | diabetes, body mass index, | ||
| - | waist/hip ratio, insulinemia | |||
| - | glycemia, triglyceride, total cholesterol | |||
| French families with morbid obesity | [17] | |||
| FABP2 | - | body mass index, adult life body with gain | ||
| fasting leptin, insulin, glycerol, free fatty acid | ||||
| B. Linkage study | ||||
| Mexican American diabetic pedigrees | [18] | |||
| FABP2 | - | diabetes | ||
| French diabetic pedigrees | [19] | |||
| FABP2 | - | diabetes | ||
| Pedigrees with lipodystrophic diabetes | [20] | |||
| FABP2 | - | lipodystrophic diabetes | ||
| French families with morbid obesity | [17] | |||
| FABP2 | - | obesity | ||
| C. Population association study | ||||
| UK, Finnish and Welsh population | [21] | |||
| FABP2 | - | diabetes/impaired glucose tolerance | ||
| Pima Indian population | [9] | |||
| A54T | - | diabetes | ||
| Japanese population | [22] | |||
| FABP2 | - | diabetes/impaired glucose tolerance | ||
| Aboriginal Canadians population | [28] | |||
| A54T | - | diabetes | ||
| Canadian Inuit population | [26] | |||
| A54T | - | coronary artery disease | ||
| Diabetic and nondiabetic Finnish population | [27] | |||
| A54T | - | coronary artery disease | ||
| Japanese population | [23] | |||
| A54T | - | diabetes | ||
| Japanese population | [24] | |||
| A54T | - | diabetes, obesity, hypertension | ||
| African Americans population | [25] | |||
| A54T | - | diabetes | ||
| D. Quantitative association study | ||||
| Non-diabetic Pima Indians | [9] | |||
| A54T | + | fasting insulin, fasting fat oxidation | ||
| + | glucose uptake | |||
| Aboriginal Canadians | [13] | |||
| A54T | + | body mass index, percent body fat | ||
| + | fasting plasma triglyceride | |||
| Finnish non-diabetic and diabetic subjects | [31] | |||
| A54T | - | insulin sensitivity | ||
| Obese Finnish subjects | [32] | |||
| A54T | - | fatty acid composition | ||
| Japanese subjects without fasting hyperglycemia | [14] | |||
| A54T | + | 2-hour post challenge insulin, | ||
| + | intraabdominal fat | |||
| Aboriginal Canadians | [36] | |||
| A54T | + | plasma triglyceride | ||
| Finnish patients with familial combined hyperlipidemia | [29] | |||
| A54T | + | lipid oxidation rate, HDL triglycerides, | ||
| + | LDL triglyceride | |||
| - | insulin sensitivity | |||
| Obese Finnish subjects | [33] | |||
| A54T | - | fasting insulin, glucose, lipid | ||
| - | lipoprotein, basal metabolic rate, | |||
| - | glucose and lipid oxidation | |||
| Japanese population | [23] | |||
| A54T | - | insulin sensitivity | ||
| Japanese population | [24] | |||
| A54T | - | dyslipidemia, hyperuricemia | ||
| - | hyperinsulinemia | |||
| Guadeloupe Indian population | [30] | |||
| A54T | + | triglyceride | ||
| American Caucasian population | ** | |||
| A54T | + | insulin sensitivity (%S) | ||
| E. Interventional study | ||||
| Response to dietary fiber in Canadian subjects | [36] | |||
| A54T | + | greater decreases in total | ||
| + | LDL cholesterol and Apo-B | |||
| Postprandial lipemic response in normotriglyceridemic subjects | [35] | |||
| A54T | + | greater increases in chylomicron and VLDL triglycerides! | ||
* "+" denotes positive association or linkage and "-" denotes negative association or linkage; **the present study