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In vitro effect of 5-aza-2′-deoxycytidine treatment of primary cultures of parathyroid adenoma cells (n=18) showing restoration of gene expression of CDKN2A, CDKN2B, WT1, SFRP1, SFRP2 and SFRP4 after treatment at 24 and 48 hours compared to untreated cells (control). Target gene/GAPDH mRNA ratio was determined by quantitative RT-PCR analysis, normalized values are presented. Gene expression restoration was significant in all experiments (P ≤ 0.05)
