TABLE 1.
The Top-50 Most Differentially Hypermethylated Genes in Parathyroid Adenomas Versus Normal Parathyroid Glands.
| Gene symbol | P Value | β-value difference | Function |
|---|---|---|---|
| CDKN2B* | 0.001 | 0.728 | Tumor suppressor |
| RAMP1 | 0.034 | 0.445 | Protein transport |
| KCTD1 | 0.002 | 0.431 | Ion channel |
| SEMA3F | 0.002 | 0.430 | Unknown |
| SOCS3 | 0.006 | 0.417 | Anti- apoptosis |
| ESPN | 0.002 | 0.408 | Cell adhesion |
| SFRP1 | 0.003 | 0.401 | Cell differentiation |
| GJA5 | 0.012 | 0.399 | Connexon channel |
| TNFRSF10C* | 0.011 | 0.381 | Signal transduction, apoptosis |
| NBL1 | 0.003 | 0.0378 | Cell cycle regulator |
| SCARA3 | 0.040 | 0.378 | response to oxidative stress |
| APC* | 0.007 | 0.372 | Tumor suppressor |
| PRDM2 | 0.003 | 0.372 | Transcription factor |
| HCG9* | 0.011 | 0.370 | Unknown |
| CDKN2A | 0.009 | 0.365 | Tumor suppressor |
| MCAM | 0.038 | 0.363 | Cell adhesion |
| SLC2A3 | 0.049 | 0.357 | Glucose transport |
| BHMT2 | 0.001 | 0.355 | Homocysteine S-methyltransferase |
| P8 | 0.007 | 0.354 | Apoptosis |
| PDGFRB | 0.012 | 0.353 | Signal transduction |
| RASSF2 | 0.020 | 0.350 | Signal transduction |
| TMPRSS2 | 0.009 | 0.349 | Proteolysis |
| PIK3R2 | 0.013 | 0.347 | Apoptosis |
| GNB4 | 0.019 | 0.347 | Signal trasduction |
| WT1 | 0.006 | 0.344 | Transcription factor, cell cycle regulator |
| PSKH2 | 0.022 | 0.342 | Kinase, tranferase |
| SLC16A3 | 0.003 | 0.329 | Anion transport |
| CFTR | 0.032 | 0.329 | Ion channel |
| PSTPIP1 | 0.012 | 0.328 | Signal transduction |
| SFRP4 | 0.006 | 0.325 | Cell differentiation |
| GIMAP1 | 0.001 | 0.324 | Immunity associated protein |
| GIMAP5 | 0.015 | 0.320 | Immunity associated protein |
| KCNE3 | 0.005 | 0.320 | Ion transport |
| RASSF1 | 0.004 | 0.319 | Cell cycle regulator |
| ADCY9 | 0.009 | 0.318 | Signal transduction |
| C20orf100 | 0.026 | 0.318 | Transcription |
| ANXA6 | 0.021 | 0.316 | Calcium ion binding |
| SFRP2 | 0.001 | 0.315 | Cell differentiation |
| C12orf34 | 0.003 | 0.315 | Unknown |
| FZD2 | 0.017 | 0.315 | Signal transduction |
| CA3 | 0.020 | 0.314 | Metal ion binding |
| KIF17 | 0.021 | 0.311 | Protein transport |
| TGIF | 0.001 | 0.310 | Transcription |
| WDR72 | 0.023 | 0.309 | Unknown |
| RB1 | 0.006 | 0.309 | Cell cycle regulator, transcription |
| GPR132 | 0.010 | 0.308 | Signal transduction |
| HIST1H4I | 0.016 | 0.306 | Maintenance of chromatin architecture |
| ANGPTL2 | 0.008 | 0.303 | Development |
| DNAJB8 | 0.029 | 0.303 | Protein folding |
| RRP22 | 0.016 | 0.301 | Transduction |
*
indicates genes where multiple CpG islands were differentially hypermethylated. Genes in bold were analyzed in the validation cohort of parathyroid tumors. β - Value Difference is the difference between the raw β – Values parathyroid adenomas and normal parathyroid tissue.