Table 6.
Analysis of the CAMPCS averaged across 500 replicated studies. At each replicate we subsampled according to four designs: random sampling of 190 individuals and then three ODS designs. Design sampled individuals who did not exhibit symptoms during follow-up, individuals who exhibited symptoms on at least one but not all interim history reports, and who exhibited symptoms on all of them. We display average parameter estimates and square roots of average variances to approximate standard errors. Estimates from the random sampling design were obtained via maximum likelihood while those for the ODS designs were obtained via ACML.
| Original cohort | Random Sampling | D[0, 190, 0] | D[10, 180, 0] | D[25, 165, 0] | |
|---|---|---|---|---|---|
| Intercept | −1.77 (0.26) | −1.83 (0.42) | −1.18 (0.37) | −1.38 (0.39) | −1.54 (0.39) |
| Time (per year) | 0.08 (0.12) | 0.09 (0.20) | 0.09 (0.14) | 0.10 (0.14) | 0.10 (0.14) |
| IL-10 Locus 6 | 0.35 (0.24) | 0.36 (0.38) | 0.36 (0.32) | 0.36 (0.34) | 0.36 (0.33) |
| Time (per year) · IL-10 Locus 6 | −0.37 (0.21) | −0.38 (0.35) | −0.43 (0.23) | −0.41 (0.23) | −0.41 (0.24) |
| Baseline age (years) | −0.17 (0.05) | −0.17 (0.08) | −0.14 (0.08) | −0.17 (0.09) | −0.19 (0.09) |
| Female (versus male) | 0.26 (0.16) | 0.25 (0.27) | 0.44 (0.25) | 0.47 (0.27) | 0.45 (0.26) |
| Race (versus white) | |||||
| African American | 0.02 (0.27) | 0.01 (0.44) | −1.13 (0.44) | −0.94 (0.42) | −0.67 (0.41) |
| Asian | 0.44 (0.31) | 0.42 (0.51) | −0.50 (0.50) | −0.30 (0.50) | −0.08 (0.48) |
| Other | −0.32 (0.33) | −0.37 (0.56) | −0.12 (0.51) | −0.21 (0.56) | −0.25 (0.53) |
| Season (versus Winter) | |||||
| Spring | −0.28 (0.14) | −0.28 (0.23) | −0.29 (0.16) | −0.28 (0.16) | −0.28 (0.16) |
| Summer | −0.89 (0.16) | −0.91 (0.26) | −0.94 (0.18) | −0.92 (0.18) | −0.92 (0.18) |
| Fall | −0.33 (0.15) | −0.34 (0.24) | −0.29 (0.16) | −0.29 (0.16) | −0.30 (0.17) |
| City (versus Baltimore) | |||||
| Albuquerque | −0.52 (0.37) | −0.54 (0.61) | −0.66 (0.62) | −0.73 (0.63) | −0.68 (0.59) |
| Boston | 0.35 (0.29) | 0.36 (0.48) | 0.14 (0.41) | 0.20 (0.45) | 0.25 (0.45) |
| Denver | −0.36 (0.33) | −0.35 (0.53) | −0.87 (0.53) | −0.80 (0.54) | −0.64 (0.51) |
| San Diego | −0.21 (0.36) | −0.23 (0.59) | −0.07 (0.53) | −0.13 (0.57) | −0.14 (0.56) |
| Seattle | 0.08 (0.29) | 0.11 (0.47) | −0.17 (0.41) | −0.16 (0.46) | −0.13 (0.46) |
| St. Louis | −0.15 (0.29) | −0.15 (0.47) | 0.06 (0.41) | 0.01 (0.46) | −0.02 (0.46) |
| Toronto | −0.42 (0.31) | −0.42 (0.50) | −0.77 (0.47) | −0.79 (0.50) | −0.72 (0.49) |
| Dependence model parameters | |||||
| γ | 0.04 (0.22) | 0.04 (0.35) | 0.02 (0.22) | 0.02 (0.22) | 0.02 (0.24) |
| log(σ) | 0.25 (0.10) | 0.18 (0.18) | −0.25 (0.30) | −0.01 (0.21) | 0.08 (0.17) |
Note: CAMPCS data were obtained with permission from the CAMP Data Coordinating Center.