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. Author manuscript; available in PMC: 2012 Sep 1.
Published in final edited form as: Free Radic Biol Med. 2011 Jan 28;51(5):951–966. doi: 10.1016/j.freeradbiomed.2011.01.026

Fig. 1. Superoxide and peroxynitrite are targets for novel pain therapy.

Fig. 1

Superoxide (O2·−) and peroxynitrite (ONOO−) are key mediators in the development of peripheral and central sensitization of the various pain etiologies. The use of superoxide-dismutase mimetics (SODm, i.e. SC-72325) and peroxynitrite decomposition catalysts (PNDCs, i.e. FeTMPyP) reduce nitroxidative stress and attenuate the development of peripheral and central sensitization; providing promising novel therapy for chronic pain management.