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. Author manuscript; available in PMC: 2012 Mar 15.
Published in final edited form as: Oncogene. 2011 Apr 4;30(37):3943–3952. doi: 10.1038/onc.2011.105

Fig. 7. Schematic illustration of H3S28ph mediating Pol III gene transcription.

Fig. 7

EGF induces H3S28ph through the EGFR pathway. H3S28ph increases TFIIIB expression, which in turn regulates Pol III gene transcription. H3S28ph also directly upregulates Pol III gene transcription. Both direct and indirect roles of H3S28ph enhance Pol III gene activity to promote cell transformation.