Table I.

The Effect of Span/Cholesterol Ratio on Vesicle Size, its Distribution, and Drug Entrapment Efficiency

Span/cholesterol molar ratio	z-average diameter (nm)	PDI	Drug content in 10 mg lyophilized powder			Entrapment efficiency (%) mean ± SD
			Theoretical amount of drug (mg)	Un-entrapped drug (mg)	Entrapped drug (mg)
7:4	298.0	0.607	0.1724	0.1368 ± 0.0004	0.0357 ± 0.0061	20.71 ± 3.52
7:6	587.9	0.504	0.1613	0.1105 ± 0.0007	0.0521 ± 0.0035	32.27 ± 2.18
7:8	316.7	0.478	0.1515	0.1085 ± 0.0025	0.0382 ± 0.0011	25.24 ± 0.73