Table II.

Effect of Span/Cholesterol Ratio on Drug Release Characteristics of Lyophilized Powder in pH 7.4 PBS Solution and Kinetic Modeling of Drug Release Data

Span/cholesterol molar ratio	t 50% (h) mean ± SD	Zero order		First order		Higuchi model
		K 0 (%/h)	r 2	K 1 (h−1)	r 2	K H (h−1/2)	r 2
7:4	1.08 ± 0.08	9.7317	0.9132	0.379304	0.9832	31.609	0.9885
7:6	1.58 ± 0.18	9.6543	0.9287	0.297548	0.9970	31.191	0.9947
7:8	0.80 ± 0.10	8.8244	0.9150	0.534066	0.9239	28.616	0.9874

K ₀ zero order, K ₁ first order, K _H Higuchi’s rate constant, r ² is the correlation coefficient