Table III.
Effect of Span/Cholesterol Ratio on Drug Release Characteristics of Isolated Nanovesicles in pH 7.4 PBS Solution and Kinetic Modeling of Drug Release Data
| Span/cholesterol molar ratio | t 50% (h) mean ± SD | Zero order | First order | Higuchi model | |||
|---|---|---|---|---|---|---|---|
| K 0 (%/h) | r 2 | K 1 (h−1) | r 2 | K H (h−1/2) | r 2 | ||
| 7:4 | 6.25 ± 0.31 | 5.8994 | 0.9698 | 0.096956 | 0.9915 | 23.286 | 0.9945 |
| 7:6 | 7.53 ± 0.23 | 6.1033 | 0.9834 | 0.091659 | 0.9908 | 23.751 | 0.9802 |
| 7:8 | 5.35 ± 0.15 | 5.9164 | 0.9621 | 0.102944 | 0.9882 | 23.435 | 0.9935 |
K 0 zero order, K 1 first order, K H Higuchi’s rate constant, r 2 is the correlation coefficient