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Factors Influencing the Drug Release from Suppository Formulations (36)
| Rectal environment | Drug substance | Matrix |
|---|---|---|
| Fluid volume | Solubility | Composition |
| Composition | Surface properties | Melting behavior |
| pH | Particle size | Surface tension |
| Buffer capacity | Drug concentration | Rheological behavior |
| Surface tension | pKa | |
| Viscosity | ||
| Luminal pressure |
