Table IV.
Physical Properties and NCT Release Characteristics of NCT–MAS Complex-Loaded SA Tablets
| Tablets | Thickness (mm) | Hardness (N) | NCT release | |
|---|---|---|---|---|
| Release exponent, n | Release rate (% min−1) | |||
| Preparation pH of complexes | ||||
| pH 4 | 1.46 ± 0.02 | 70.6 ± 2.7 | 1.05 ± 0.07 (R 2 = 0.992) | 0.14 ± 0.01 (R 2 = 0.962) |
| pH 7 | 1.58 ± 0.02 | 58.8 ± 0.1 | 0.92 ± 0.05 (R 2 = 0.990) | 0.15 ± 0.02 (R 2 = 0.980) |
| pH 9 | 1.61 ± 0.01 | 60.8 ± 2.7 | 0.98 ± 0.07 (R 2 = 0.992) | 0.15 ± 0.03 (R 2 = 0.997) |
| Complex/SA ratio | ||||
| 1:4 | 1.71 ± 0.02 | 48.8 ± 3.2 | 0.77 ± 0.03 (R 2 = 0.992) | 0.14 ± 0.02 (R 2 = 0.996) |
| 1:1.5 | 1.69 ± 0.02 | 39.2 ± 0.1 | 0.85 ± 0.04 (R 2 = 0.992) | 0.12 ± 0.01 (R 2 = 0.999) |
| 1:0.67 | 1.61 ± 0.01 | 60.8 ± 2.7 | 0.98 ± 0.07 (R 2 = 0.992) | 0.15 ± 0.03 (R 2 = 0.997) |
| 1:0 | 1.42 ± 0.01 | 68.6 ± 0.1 | 0.46 ± 0.01 (R 2 = 0.972) | 3.20 ± 0.08a (R 2 = 0.988) |
| Pure SA | 1.87 ± 0.02 | 14.7 ± 3.5 | ND | ND |
| Pure MAS | 1.31 ± 0.01 | 36.3 ± 4.4 | ND | ND |
Data are the mean ± SD, n = 3
ND not determined
aCalculated from Higuchi model (unit, % min−1/2)