Table I.

Pharmacokinetic Parameters of DTX After Intravenous Infusion Administration of a Single 7.5-mg/kg Dose of DTX/HP-SBE-β-CD and Taxotere® to Rabbits (n = 6)

Drug (mg/kg)	DTX/HP-SBE-β-CD	Taxotere®
V d (L/kg)	0.836 ± 0.173	1.080 ± 0.295
t 1/2α (h)	0.215 ± 0.026	0.283 ± 0.056
t 1/2β (h)	5.182 ± 1.485	5.989 ± 1.394
AUC0–24h (mg/L/h)	3.740 ± 0.754	3.530 ± 0.326
AUC0-∞ (mg/L/h)	3.885 ± 0.752	3.907 ± 0.331
CL (L/h/kg)	2.006 ± 0.420	2.124 ± 0.211
MRT (h)	2.750 ± 0.356	2.469 ± 0.713

All data are presented as mean ± SD (n = 6)

V _d apparent volume of distribution, t _1/2α plasma half-life for the distribution phase, t _1/2β plasma half-life for the elimination phase, AUC _0-24h area under the plasma concentration–time curve from 0 to 24 h, AUC _0-∞ area under the plasma concentration–time curve from time zero to infinity, CL total body clearance, MRT mean residence time, DTX docetaxel, HP-SBE-β-CD hydroxypropyl-sulfobutyl-β-cyclodextrin