. 2011 May 17;12(2):665–672. doi: 10.1208/s12249-011-9631-0

Table III.

Airway Reactivity Measurement and Histamine Levels in BALF at Last Challenge in Experimental Rats

Group	Time of last challenge	Airway reactivity measurement			Histamine in BALF (nM/mL)
Group	Time of last challenge	Re (cmH₂O/mL/s)	Ri (cmH₂O/mL/s)	Cldyn (mL/cmH₂O)	Histamine in BALF (nM/mL)
Negative control	D₁₄	0.797 ± 0.106	0.571 ± 0.053	0.087 ± 0.004	2.35 ± 0.843
Negative control	D₂₁	0.863 ± 0.093	0.611 ± 0.060	0.085 ± 0.004	2.43 ± 0.806
Positive control	D₁₄	1.347 ± 0.150**	1.028 ± 0.125**	0.053 ± 0.007**	18.4 ± 4.057**
Positive control	D₂₁	1.380 ± 0.136**	1.093 ± 0.107**	0.051 ± 0.006**	15.4 ± 4.473**
DTX/HP-SBE-β-CD	D₁₄	0.836 ± 0.049	0.611 ± 0.034	0.086 ± 0.007	3.83 ± 1.357
DTX/HP-SBE-β-CD	D₂₁	0.830 ± 0.035	0.666 ± 0.161	0.089 ± 0.003	3.15 ± 0.850

Data represent mean value ± SD, n = 4

*p < 0.05; **p < 0.01 (compared with negative control)

Re expiratory resistance, Ri inspiratory resistance, Cldyn dynamic pulmonary compliance, DTX docetaxel, HP-SBE-β-CD hydroxypropyl-sulfobutyl-β-cyclodextrin, BALF bronchoalveolar lavage fluid