Table II.
Type of container | Percentage of drug loss in 30 min (0.5 μg/ml, 5%v/v ethanol) | Percentage of drug loss in 30 min (0.15 μg/ml, 0.5% v/v ethanol) |
---|---|---|
Polyethylene inserts | 86.4 and 76.0 (n = 2) | ND |
Polypropylene inserts | 78.7 ± 8.1 | ND |
Ultra high grade Polypropylene | 41.2 ± 4.7 | 47.0 ± 2.3 |
Clear glass vial (20 mL) | 1.8 ± 1.6 | 1.7 ± 1.3 |
Clear glass vial (5 mL) | 0.9 ± 1.1 | 1.9 ± 1.4 |
HPLC vials (1 mL) | 0 | 1.4 ± 1.8 |
These studies were carried out for 30 min at room temperature. Values are represented as mean ± sd (n = 6). All glass vials used in this study met USP Type I specification
ND not detectable