Fig. 2.

Spatial learning and memory of Abcg5−/− compared to Abcg5+/+ mice in the MWEM. Spatial memory performance did not differ between Abcg5+/+ and Abcg5−/− mice in the MWEM. Acquisition times (a) and distance moved were not different between the Abcg5+/+ (n = 9) and Abcg5−/− (n = 8). Abcg5−/− mice swam significantly faster than the Abcg5+/+ mice (b). In a probe trial without platform, all mice spent significantly more time searching in the target zone and no differences were found between Abcg5+/+ and Abcg5−/− mice (c). Using software the pool was divided into 4 virtual quadrants and a target zone. Values are displayed as mean +/− SEM, *=P < 0.05