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. Author manuscript; available in PMC: 2012 Jul 1.
Published in final edited form as: Crit Care Clin. 2011 Jul;27(3):661–683. doi: 10.1016/j.ccc.2011.04.001

Figure 2.

Figure 2

Schematic representation of an alveolus and the alveolar-capillary interface demonstrating causes, pathophysiology and important potential biomarkers for prediction, diagnosis and prognosis in acute lung injury. Abbreviations, RBC = red blood cell. T1 = type 1 epithelial cell. T2 = type 2 epithelial cell. ICAM-1=Intercellular adhesion molecule 1. vWF = von Willebrand factor. PAI-1 = Plasminogen activator inhibitor 1. SP = surfactant protein. RAGE = Receptor for Advanced Glycation Products. HMGB1= Human Mobility Group Box 1 protein. TNFR-1 = Tumor Necrosis Factor Receptor 1.