Receiver Operator Characteristic curve for multiple mortality prediction models in patients with acute lung injury. Full model includes six clinical predictors (age, cause of injury, APACHE III, plateau pressure, organ failures, alveolar-arterial difference and eight biomarkers (IL-8, IL-6, TNFR-1, SP-D, Protein C, PAI-1, ICAM-1) and has an AUC 0.850. The reduced model includes APACHE III score, age, surfactant protein D and interleukin 8 with an AUC 0.834. From Ware LB et al. Chest. Feb 2010;137(2):292, with permission.