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. Author manuscript; available in PMC: 2012 Jul 1.
Published in final edited form as: Crit Care Clin. 2011 May 23;27(3):719–733. doi: 10.1016/j.ccc.2011.04.004

Table 1.

MSCs in Models of Acute Lung Injury

Reference Injury model MSCs given Beneficial effects Increased Decreased Other
38 Intratracheal LPS in mice Intratracheally, 4 hrs after LPS; Sac at 24 and 48 hrs ↓Lung edema
↓Lung hemorrhage
↓BAL protein
↓Mortality		 IL-10 MIP-2, TNF-α No significant engraftment
37 Intraperitoneal LPS in mice Intravenously, 1 hour after LPS; Sac at 6, 24, 48 hrs and 14 days ↓Lung PMNs
↓Lung edema		 IFN-γ, IL-1β, MIP-1α, KC No significant engraftment
40 Cecal ligation and puncture in mice Intravenously 6 hours after CLP; Sac at 28 hrs ↓BAL cell counts
↓BAL albumin
↓Lung Edema and inflammation
↓Kidney injury
↓Mortality		 IL-6, IL-1β, IL-10, KC, JE, CCL5 Microarray analysis: downregulation of inflammatory genetic pathways; Enhanced bacterial clearance
41 Cecal ligation and puncture in mice Intravenously 24 hours before or 1 hour after CLP; Sac at 1 and 4 days ↓Kidney injury
↓Transaminases
↓Splenic apoptosis
↓Mortality
↓Tissue myelo-peroxidase		 IL-10, PGE2 TNF-α and IL-6 In vitro MSCs reprogram monocytes/macrophages to secrete IL-10
39 Intratracheal E-coli in mice Intratracheally 4 hours after E-coli; Sac at 18 hrs ↓BAL neutrophils
↓BAL protein		 MIP-2 MSC-produced LL-37 decreases bacterial growth in vitro and BAL bacterial growth in vivo