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. Author manuscript; available in PMC: 2012 Jul 13.
Published in final edited form as: Structure. 2011 Jul 13;19(7):930–944. doi: 10.1016/j.str.2011.05.002

Figure 4. KH1-RNA Interactions in Complex.

Figure 4

(A) Overview of interactions between RNA hairpin loop (U9 to G12 in gold and the U13 to C16 in cyan, see insert) and the N-terminal half of the KH1 domain (Tyr15 to Lys45 in gold, encompassing α1, loop I, α2 and β2 segments). Bridging water molecules at the interface are labeled w1, w2 and w3.

(B) Details of intermolecular contacts involving the C14-A15 segment of the RNA, and amino acids Arg54, Lys41 and Gln32 of the KH1 domain. Note buttressing interactions between the base and sugar of A11 and C14. The side chain of Lys40 is removed for clarity.

(C) Details of intermolecular contacts involving U13 base and sugar hydroxyl group of the RNA, and backbone atoms of amino acids Gly18, Gly22 and Lys23 of the KH1 domain.

(D) Intermolecular contacts between the Watson-Crick edge of C16 and the side chain amine (hydrogen bonding) and methylene groups (van der Waals) of Lys40.