Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Electrophysiology effects of the hermitamides on hNav1.2.
| Compound | 10 μM | 1 μM | 100 nM |
|---|---|---|---|
| (rac)-4 | 90.2 ± 2.5 (3) | 49.7 ± 3.8 (4) | <10 (3) |
| (S)-4 | 94.4 ± 1.3 (4) | 74.4 ± 2.1 (4) | 15.5 ± 3.7 (4) |
| (R)-4 | 58.7 ± 1.3 (4) | <10 (3) | |
| (rac)-5 | 100 (1) | 88.4 ± 2.9 (4) | 24.3 ± 2.9 (4) |
| (S)-5 | 100 (3) | 87.8 ± 2.2(4) | 17.2 ± 2.4(4) |
| (R)-5 | 80.7 ± 2.2(4) | 28.8 ± 3.0 (4) | |
| Phenytoin | 10 | <10 (3) |
Values represent percentage block (%) ± S.E.M. Values in parenthesis represent n numbers of experiments.
