Fig. 2.

Cell cycle arrest and apoptotic effects of berbamine on KU812 cells

(a) Effect of berbamine on cell cycle arrest. KU812 cells were untreated or treated with 4 μg/ml berbamine for 0, 6, 12, or 24 h, after which the cells were stained with PI and analyzed for DNA content by FCM. (b) Apoptosis induction of berbamine. KU812 cells were untreated or treated with 8 μg/ml berbamine for 0, 6, 12, or 24 h. Percentages of apoptotic cells were determined by staining with annexin V and PI on FCM