Tab. 2.

Percentage of Inhibition Caused by Ibuprofen and Its Conjugates in Carrageenan-Induced edema in Wistar rats (150–200 g)

Treatment	Dose (mg/kg)	1 hr.	2 hr	3 hr	4 hr	8 hr	24 hr
Control	–	0.59 ± 0.005	0.68 ± 0.007	0.48 ± 0.009	0.43 ± 0.011	0.32 ± 0.005	0.27 ± 0.006
Standard	20	0.33 ± 0.013**	0.48 ± 0.017**	0.38 ± 0.013**	0.24 ± 0.009**	0.15 ± 0.010ns	0.03 ± 0.013ns
PEG600-Ibu Conjugate	52.60	0.22 ± 0.008***	0.33 ± 0.007***	0.43 ± 0.012**	0.37 ± 0.014**	0.30 ± 0.009**	0.17 ± 0.010**
PEG4000-Ibu Conjugate	214	0.25 ± 0.011**	0.36 ± 0.010**	0.45 ± 0.018**	0.40 ± 0.014**	0.34 ± 0.007**	0.20 ± 0.011**

Value are expressed in mean ± SEM;

^*p< 0.05,

^**p< 0.01, and

^***p< 0.001; One-way Anova followed by Dunnet’s test.