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. 2011 Jan 20;1:147. doi: 10.3389/fphar.2010.00147

Table 2.

Reference chemicals tested in the intra-laboratory pre-validation of an in vitro angiogenesis assay.

Chemical name CAS-RN Chemical class Product class Concentrations tested Purity Supplier Physical and chemical characteristics
Acetyl salicylic acid 50-78-2 Salicylate Non-steroidal anti-inflammatory drug (NSAID) 10, 100, 500, 1000, 1500, and 2000 μM 99.9% Sigma Aldrich Powder
Erlotinib 183319-69-9 Quinazoline HER1/EGFR tyrosine kinase inhibitor 0.0005, 0.001, 0.01, 0.1, 1, 10, 25, and 50 μM 99.9% Roche Diagnostics Powder
Levamisole 16595-80-5 Imidazothiazole Alkaline phosphatase inhibitor 0.01, 0.1, 1, 10, 50, 100, 250, 500, 750, 1000, and 2000 μM 99% Sigma Aldrich Powder
2-Methoxyestradiol 363-07-2 Estradiol metabolite Tubulin inhibitor 0.01, 0.1, 0.2, 0.4, 0.6 0.8, 1, and 2 μM 99.5% Sigma Aldrich Powder
Thalidomide 50-35-1 Phthalimide Immunomodulator, TNF-α inhibitor 10, 100, 200, 300, 400, and 500 μM >99% Sigma Aldrich Powder
Anti-VEGF n/a Human VEGF165 and VEGF121 antibody, IgG fraction of antiserum Growth factor antibody 0.5, 1, 2.5, 5, 7.5, 10, 25, and 50 μg/ml n/a Sigma Aldrich Lyophilized powder