Acetyl salicylic acid |
1.8–8 μg/ml (10–100 μM) |
180 μg/ml (1000 μM) |
270 μg/ml (1500 μM) |
Moderate 500 μM (Borthwick et al., 2006) |
• 260–1026 μM (Juárez Olguín et al., 2004) |
• 26–300 μM, CAM model (Sharma et al., 2001) |
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• 0–25 μg/ml (Maalouf et al., 2009) |
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• 170 ± 96.7 ng/ml (Bae et al., 2008) |
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Erlotinib (EGF receptor tyrosine kinase inhibitor) |
0.04–40 ng/ml (0.5 nM–0.1 μM) |
4 μg/ml (10 μM) |
22 μg/ml (50 μM) |
Mild 1–20 μM (Birle and Hedley, 2006), Moderate 10 μM (Jimeno et al., 2007) |
• 0.3–1.13 μg/ml (Herbst et al., 2005) |
• 50 mg/kg, Mouse carcinoma model (Jimeno et al., 2007) |
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• 0.251–10.7 μg/ml (Ranson et al., 2010a) |
• 50 mg/kg, Mouse tumor model (Cerniglia et al., 2009) |
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• 2.93 ± 1.3 μg/ml (Ranson et al., 2010b) |
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• 0.3 μM (Clarke et al., 2010) |
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• 0.56–4 μM (Kraut et al., 2010) |
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Levamisole |
2–240 ng/ml (0.01–1 μM) |
25–120 μg/ml (100–500 μM) |
240–500 μg/ml (1000–2000 μM) |
Mild 500 μM, moderate 750–1000 μM, strong 2000 μM (Friis et al., 2005), strong 2000 μM (Sylvest et al., 2010) |
• 0.62 μg/ml–1.27 μg/ml (Reid et al., 1998) |
• 1.2–12 mg/kg, Nude mouse tumor model (Friis et al., 2005) |
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• 0.716 ± 0.217 μg/ml (Kouassi et al., 1986) |
• Cmax 0.37 μg/ml calf parasite infection (Taylor et al., 1988
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2-Methoxyestradiol |
3–60 ng/ml (0.01–0.2 μM) |
300 ng/ml (1 μM) |
600 ng/ml (2 μM) |
Mild 10 μM, moderate 50 μM (Kang et al., 2006), Mild 0.5 μM, moderate 1 μM (Dobos et al., 2004) |
• 3.3 ng/ml (Tevaarwerk et al., 2009) |
• 100 mg/kg Murine rheumatoid arthritis model (Plum et al., 2009) |
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• 30.27 ± 20.18 ng/ml (Matei et al., 2009) |
• 7.5 mg/kg, 75 mg/kg Mouse tumor model (Dobos et al., 2004) |
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• 3.0–21.4 ng/ml (Dahut et al., 2006) |
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• 1.4–13.2 ng/ml (James et al., 2007) |
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• 2.2–9.6 ng/ml (Sweeney et al., 2005) |
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Thalidomide |
2–25 μg/ml (10–100 μM) |
77–100 μg/ml (300–400 μM) |
- |
- |
• 2 μg/ml (Kakimoto et al., 2002) |
• 100 mg/kg, Rat Alzheimer model (Ryu and McLarnon, 2008) |
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• 1.68 ± 0.41 μg/ml (Murakami et al., 2009) |
• 19–1000 μM, CAM model (Sharma et al., 2001) |
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• 1.44 ± 0.50 μg/ml (Kamikawa et al., 2006) |
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• 0.43–1.03 μg/ml (Vieira and Valente Mdo, 2009) |
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Anti-VEGF |
0.01–0.1 μg/ml |
0.5–1 μg/ml |
25–50 μg/ml |
Strong 0.1 mg/ml-10 mg/ml (Sims et al., 2008), Strong 5 μg/ml (Friis et al., 2006), Strong 10 μg/ml (Friis et al., 2003) |
• 363 μg/ml (Herbst et al., 2005) |
• 2–4 mg/kg, Mouse carcinoma model (Sims et al., 2008) |
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• 123.2 ± 16.4 μg/ml (Wu et al., 2010) |
• Cmax 104.46 ± 1.44 ng/ml, injection in rabbit (Kim et al., 2010) |
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• 11.94–194.08 μg/ml (Ning et al., 2010) |
• Cmax 1430 ± 186 ng/ml, vitreous injection macaque eyes (Miyake et al., 2010) |
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• 20.7–24.2 ng/ml (Sharma et al., 2010) |
• Cmax 676 ± 100 μg/ml, cynomolgus monkeys (Xu et al., 2008) |
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• 16.6–42.5 μg/ml (Krohne et al., 2008) |
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• 2.63–165 μg/ml (Zhu et al., 2008) |
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