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Overexpression of SirT3 negatively regulates proliferation and tumorigenesis. Inducible overexpression of GFP and SirT3 in 143B (a) and HCT116 (b) decreases proliferation. Tumor volume (c) and tumor mass (d) of HCT116 GFP or SirT3 cells injected into the flanks of Nu/Nu mice. Doxycycline was added on day 9 to induce expression of GFP or SirT3. Error bars are s.e.m. and * indicates a P value <0.05 with two-tailed Student's t-test. (e) Pictures of tumors from c and d.
