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. 2011 Jun 22;31(25):9404–9413. doi: 10.1523/JNEUROSCI.1317-11.2011

Figure 5.

Figure 5.

Relative expression of mRNA levels for a variety of proteins in the CNS of npc1+/+ and npc1−/− mice treated with HP-β-CD. A single dose of HP-β-CD (35 mg/kg) or aCSF was administered into the left cerebral ventricle of 49-d-old npc1+/+ and npc1−/− mice. Twenty-four hours later, the brains were removed and mRNA was extracted. A–E, The mRNA levels for SREBP2 and its target genes, HMG CoA RED, HMG CoA SYN, LDLR, and PCSK9, that control the rates of C acquisition and synthesis. F–H, mRNA levels for the genes ABCA1, ABCG1, and MYLIP that are controlled by the nuclear receptor, LXR. I, J, NPC2 and SOAT1, genes involved in cholesterol transport and esterification. K, L, SREBP1c and FAS, two genes controlling fatty acid synthesis. M–O, Genes involved in the hydroxylation or transport of C in the brain. P–T, Genes reflecting activation, proliferation, and cytokine production by microglia in the CNS. Means ± 1 SEM (n = 4 in each group) are shown.