Figure 8.
Relative expression of mRNA for a variety of proteins in the CNS of npc1+/+ and npc1−/− mice treated chronically with HP-β-CD. Groups of both npc1+/+ and npc1−/− (n = 3 in each group) mice were given systemic, subcutaneous injections of either saline or HP-β-CD (4000 mg/kg) every 7 d (beginning at 7 d of age) along with the continuous intracerebroventricular infusion of either aCSF or HP-β-CD (27 mg · kg−1 · d−1) (between 21 and 49 d of age). All mice were killed for determination of mRNA levels at 49 d of age. The various mRNAs measured in this study correspond to those previously evaluated in mice receiving a single dose of HP-β-CD (Fig. 5).