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Decreased PDE11A protein in two adrenocortical tumors with PDE11A missense substitutions: one ACC (A) and one ACA (C). PDE11A immunostaining in three wild-type adrenocortical tumors: one ACC (B), one ACA (D), and one AIMAH (F). Immunopositivity for PDE11A in Leydig cell from normal testis tissue was used as positive control (E). Magnification, ×400 (A and E), ×200 (B and F), and ×100 (C and D).
