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. Author manuscript; available in PMC: 2012 Apr 1.
Published in final edited form as: Int J Mass Spectrom. 2011 Apr;302(1-3):69–75. doi: 10.1016/j.ijms.2010.08.003

Figure 1. Serpin Structure and Mechanism.

Figure 1

A. The structure of α1-antitrypsin (1QLP). Secondary structure elements are labeled. B. The Michaelis complex between a serpin (black) and target protease (white) (1K90). C. The covalently linked serpin-protease complex after the inhibitory conformational change (1EZX). In addition to the protease, the serpin’s inserted reactive center loop is also shown in white.