Table 2.
Distribution of VDR polymorphisms among patients with a stress fracture and controls#
| Patients* | Controls* | aOR† | 95% CI | p-Value | |
|---|---|---|---|---|---|
| FokI polymorphism | |||||
| Genotype | |||||
| FF | 10 (31.2) | 20 (62.5) | 1.0 | ||
| Ff | 18 (56.2) | 11 (34.4) | 3.7 | 1.2–11.6 | 0.028 |
| ff | 4 (12.6) | 1 (3.1) | 10.2 | 1.0–88.7 | 0.047 |
| Ff or ff | 22 (68.8) | 12 (37.5) | 4.1 | 1.3–12.7 | 0.014 |
| Allele | |||||
| F | 38 (59.4) | 51 (79.7) | |||
| f | 26 (40.6) | 13 (20.3) | 1.0 | 0.017 | |
| 2.8 | 1.2–6.3 | ||||
| BsmI polymorphism | |||||
| Genotype | |||||
| BB | 8 (25.0) | 4 (12.5) | 8.8 | 1.1–68.6 | 0.039 |
| Bb | 22 (68.8) | 19 (59.5) | 4.6 | 0.8–26.4 | 0.085 |
| bb | 2 (6.2) | 9 (28.1) | 1.0 | ||
| BB or Bb | 30 (93.8) | 23 (71.9) | 5.3 | 1.0–29.4 | 0.050 |
| Allele | |||||
| B | 38 (59.4) | 27 (42.2) | 1.0–4.4 | 0.051 | |
| b | 26 (40.6) | 37 (57.8) | 2.2 | ||
| 1.0 | |||||
| TaqI polymorphism | |||||
| Genotype | |||||
| TT | 9 (28.1) | 11 (34.4) | 1.0 | ||
| Tt | 18 (56.3) | 18 (56.3) | 1.1 | 0.3–3.7 | 0.846 |
| tt | 5 (15.6) | 3 (9.4) | 4.5 | 0.6–33.5 | 0.138 |
| Tt or tt | 23 (71.9) | 21 (65.6) | 1.4 | 0.4–4.4 | 0.577 |
| Allele | |||||
| T | 36 (56.3) | 40 (62.5) | 1.0 | ||
| t | 28 (43.8) | 24 (37.5) | 1.7 | 0.8–3.5 | 0.199 |
| ApaI polymorphism | |||||
| Genotype | |||||
| AA | 9 (28.1) | 8 (25.0) | 1.0 | ||
| Aa | 10 (31.3) | 12 (37.5) | 0.5 | 0.1–2.1 | 0.355 |
| aa | 13 (40.6) | 12 (37.5) | 0.7 | 0.2–2.7 | 0.598 |
| Aa or aal | 23 (71.9) | 24 (75.0) | 0.6 | 0.1–2.1 | 0.425 |
| Allele | |||||
| A | 28 (43.8) | 28 (43.8) | 1.0 | ||
| a | 36 (56.2) | 36 (56.2) | 0.9 | 0.4–1.8 | 0.747 |
Statistical significance for differences between patients and controls in genotypes frequencies (p=0.033, p=0.050, p=0.705, and p=0.869), f-, B-, t- and a-containing genotypes frequencies (p=0.012, p=0.020, p=0.590, and p=0.777) and allelic frequencies (p=0.013, p=0.052, p=0.472, and p=1.000) of FokI, BsmI, TaqI, and ApaI polymorphisms, respectively
Data given are number of subjects and percentage (%)
Adjusted for age, BMI, smoking, alcohol, and calcium intake
aOR: adjusted odds ratio; CI: confidence interval