Table 3.
Doppler-derived parameters (mean ± standard deviation) in dogs with chronic Chagas disease (n = 3) undergoing an intracoronary autologous stem cell transplantation
| Post-transplantation
|
||||||||
|---|---|---|---|---|---|---|---|---|
| Baseline M0 | M1 1 month | M2 2 months | M3 3 months | M4 4 months | M5 5 months | M6 6 months | P ANOVA | |
| PVPUL | 0.73 ± 0.15 | 0.77 ± 0.23 | 0.72 ± 0.15 | 0.77 ± 0.20 | 0.72 ± 0.07 | 0.76 ± 0.11 | 0.76 ± 0.18 | 0.9989 |
| PVAO | 0.80 ± 0.21 | 1.11 ± 0.02 | 1.11 ± 0.03 | 1.24 ± 0.18a | 1.15 ± 0.05a | 1.14 ± 0.08a | 1.16 ± 0.09a | 0.0111 |
| PVME | 0.52 ± 0.08 | 0.49 ± 0.10 | 0.45 ± 0.04 | 0.58 ± 0.17 | 0.54 ± 0.06 | 0.60 ± 0.12 | 0.57 ± 0.21 | 0.7660 |
| PVMA | 0.65 ± 0.18 | 0.72 ± 0.10 | 0.66 ± 0.07 | 0.72 ± 0.15 | 0.74 ± 0.15 | 0.78 ± 0.11 | 0.78 ± 0.24 | 0.8997 |
| PVTE | 0.34 ± 0.15 | 0.41 ± 0.09 | 0.42 ± 0.11 | 0.54 ± 0.20 | 0.65 ± 0.19 | 0.48 ± 0.05 | 0.47 ± 0.04 | 0.1892 |
| PVTA | 0.56 ± 0.16 | 0.70 ± 0.12 | 0.59 ± 0.13 | 0.59 ± 0.15 | 0.68 ± 0.23 | 0.74 ± 0.15 | 0.74 ± 0.15 | 0.6673 |
| PVME/PVMA | 0.82 ± 0.10 | 0.68 ± 0.06 | 0.67 ± 0.05 | 0.80 ± 0.07 | 0.75 ± 0.11 | 0.79 ± 0.24 | 0.75 ± 0.27 | 0.8442 |
| PVTE/PVTA | 0.60 ± 0.14 | 0.59 ± 0.02 | 0.72 ± 0.11 | 0.74 ± 0.07 | 0.79 ± 0.15 | 0.67 ± 0.14 | 0.65 ± 0.12 | 0.3495 |
| PEP | 69.67 ± 7.02 | 64.33 ± 7.51 | 63.33 ± 5.51 | 52.00 ± 6.73a | 50.67 ± 6.11a | 49.00 ± 5.57a | 51.00 ± 5.55a | 0.0051 |
| LVET | 217.7 ± 12.3 | 199.0 ± 35.8 | 219.0 ± 17.1 | 202.3 ± 15.8 | 217.7 ± 14.6 | 212.3 ± 15.7 | 215.0 ± 15.0 | 0.7939 |
| PEP/LVET | 0.32 ± 0.04 | 0.37 ± 0.12 | 0.34 ± 0.14 | 0.26 ± 0.05 | 0.21 ± 0.03 | 0.21 ± 0.04 | 0.21 ± 0.03 | 0.0855 |
| IVRT | 77.00 ± 13.00 | 63.00 ± 8.89 | 53.00 ± 12.07 | 58.33 ± 9.71 | 48.00 ± 6.56a | 48.33 ± 9.29a | 39.33 ± 6.04a | 0.0072 |
| SI | 49.04 ± 8.07 | 68.64 ± 10.80 | 77.65 ± 10.03 | 74.26 ± 19.81 | 73.38 ± 11.95 | 76.98 ± 8.22 | 78.90 ± 8.44 | 0.0864 |
| CI | 5.52 ± 0.66 | 7.66 ± 2.69 | 8.68 ± 2.83 | 8.05 ± 0.23 | 9.10 ± 2.00 | 8.00 ± 1.38 | 9.11 ± 1.26 | 0.2882 |
| TEI | 0.68 ± 0.02 | 0.64 ± 0.04 | 0.64 ± 0.05 | 0.51 ± 0.09 | 0.47 ± 0.03a | 0.46 ± 0.06a | 0.42 ± 0.10a | 0.0005 |
PVPUL — peak velocity of pulmonic flow (m/s); PVAO — peak velocity of aortic flow (m/s); PVME — peak velocity of mitral E wave (m/s); PVMA — peak velocity of mitral A wave (m/s); PVTE — peak velocity of tricuspid E wave (m/s); PVTA — peak velocity of tricuspid A wave (m/s); PVME/PVMA — PVME-to-PVMA-ratio; PVTE/PVTA — PVTE-to-PVTA-ratio; PEP — pre-ejection period (milliseconds); LVET — left-ventricular ejection time (milliseconds); PEP/LVET — PEP-to-LVET-ratio; IVRT — isovolumic relaxation time (milliseconds); SI — stroke index (mL/beat × m2); CI — cardiac index (L/min × m2); TEI — Tei index of myocardial performance.
Statistically different (P < 0.05) from M0 (baseline value).