Table 1.
Effects of Various Liposomes on the Viability of Plasmodium falciparum in vitro.
| Types of liposomes | IC50 in terms of phospholipid concentration (μM) |
|---|---|
| SPC | >208.33 |
| SPC: PA | >208.33 |
| SPC: SA | 24.08 ± 1.15 |
| SPC: Stearic acid (octadecanoic acid) | >208.33 |
| SPC: Stearyl alcohol (octadecyl alcohol) | >208.33 |
| SPC: myristic acid ( tetradecanoic acid) | >208.33 |
| SPC: Palmitic acid (hexadecanoic acid) | >208.33 |
| SPC: myristyl alcohol (tetradecyl alcohol) | >208.33 |
| SPC: Cetyl alcohol (hexadecyl alcohol) | >208.33 |
| Free spermidine | >1102 |
Cells with 1% parasitemia and 2% hematocrit in the presence of various concentrations of above mentioned liposomal formulations (6.5 μM–208 μM lipids) and free spermidine (34 μM–1102 μM) were treated for 42 h at 37°C (in between at 24 h, [3H] hypoxanthine was added). The cell-associated radioactivity was determined and inhibition of growth calculated by comparison with controls (without liposomes/spermidine).