Table 2.
Effect of different chain length alkylamine in SPC liposome on parasite growth after 42 h in culture.
| Types of liposomes | IC50 (μM) |
|---|---|
| SPC: Decylamine CH3(CH2)9NH2 | 43.45 ± 4.45 |
| SPC: Dodecylamine CH3(CH2)11NH2 | 24.65 ± 2.69 |
| SPC: Tetradecylamine CH3(CH2)13NH2 | 13.59 ± 1.64 |
| SPC: Hexadecylamine CH3(CH2)15NH2 | 10.44 ± 1.20 |
| SPC: Octadecylamine CH3(CH2)17NH2 | 6.87 ± 0.44 |
Parasites were treated with indicated alkylamine SPC liposome for 42 h with concentration range of (1.88 μM–60 μM alkylamine). IC50 value was assessed by measuring [3H] hypoxanthine incorporation as described in Materials and Methods. The mean value ± standard deviation is indicated for each group, and values are representative of 3 separate experiments.