Table 3.
Effect of various concentrations of SPC liposomes containing 20 mol% SA on the hemolysis of infected & uninfected erythrocytes.
| Concentration of liposomes (SA) μg/mL | % Hemolysis | |
|---|---|---|
| Infected RBC (1% parasitemia) |
Uninfected RBC | |
| 16.0 | 3.30 ± 0.34 | 0 |
| 8.0 | 1.91 ± 0.62 | 0 |
| 4.0 | 1.59 ± 0.85 | 0 |
| 2.0 | 0 | 0 |
| 1.0 | 0 | 0 |
| 0.5 | 0 | 0 |
SPC-SA liposomes at different concentrations were mixed with infected (1% parasitemia) and uninfected erythrocytes for 42 h as described in materials and methods. Percentage hemolysis was calculated using the expression % hemolysis = [A405 nm (sample) − A405 nm (negative control)]/A405 nm (positive control).