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Convergent stem cell regulatory networks control expression of key stem cell genes. One classical representative of this transcriptional network is the Zfp42/Rex1 gene. Expression of the Zfp42/Rex1 gene has long been used as a marker of undifferentiated stem cells and is regulated by Nanog, Sox2, and Oct4, and by the Wnt pathway. Expression of Zfp42/Rex1 is also subject to epigenetic regulation by polycomb complexes and DNA methylation (see Table 1).
