Table 1.
Clinical characteristics and demographics of study subjects at time of CTS symptoms
| Subject | CTS Dx | AHO Dx | Age | Sex | GH | BMI Z-score | CTS EMG | Brachymetacarpia/brachydactyly | CTS-related signs and symptoms |
Weakness | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Pain | Tingling | Numbness | Bilateral | Flick sign | Nocturnal Sx | Fine motor | ||||||||||
| 1a | + | PHP 1a | 8.3 | F | Y | 2.64 | N/A | Y | Y | U | N | Y | Y | N | Y | Y |
| 2 | + | PHP 1a | 8.5 | F | N | 3.21 | N/A | Y | Y | U | U | Y | Y | Y | Y | N |
| 3b | + | PHP 1a | 11.0 | M | N | 1.61 | N/A | Y | Y | Y | Y | Y | Y | N | Y | Y |
| 4c | + | PHP 1a | 14.0 | F | P | 2.64 | N/A | Y | Y | Y | N | N | Y | N | Y | N |
| 5 | + | PHP 1a | 14.1 | F | P | 1.02 | N/A | Y | N | Y | Y | Y | N | Y | Y | N |
| 6 | + | PHP 1a | 25.0 | F | N | 1.44 | N/A | Y | Y | Y | Y | Y | Y | N | N | N |
| 7d | + | PHP 1a | 25.2 | F | P | 2.10 | Y | Y | Y | Y | N | Y | Y | N | Y | Y |
| 8 | + | PHP 1a | 25.8 | F | P | 2.30 | Y | Y | Y | Y | Y | Y | Y | Y | N | N |
| 9d | + | PHP 1a | 28.1 | M | P | 2.24 | N/A | Y | Y | Y | Y | N | Y | N | Y | Y |
| 10 | + | PHP 1a | 38.9 | F | N | 1.9 | N/A | Y | Y | Y | Y | Y | Y | N | N | Y |
| 11 | + | PHP 1a | 41.9 | F | N | 1.78 | N/A | N | Y | Y | Y | Y | Y | N | N | Y |
| 12 | + | PHP 1a | 63.6 | F | N | 2.01 | Y | Y | Y | Y | Y | Y | Y | Y | Y | Y |
| 13 | + | PPHP | 25.4 | F | N | 1.28 | N/A | Y | Y | Y | Y | Y | Y | N | Y | Y |
| 14 | + | PPHP | 30.0 | F | N | 1.2 | N/A | Y | Y | Y | N | Y | Y | N | Y | Y |
| 15e | + | PPHP | 32.6 | F | N | 1.92 | N/A | Y | N | Y | Y | Y | Y | Y | N | Y |
| 16 | + | PPHP | 33.6 | F | N | −1.03 | Y | N | Y | Y | Y | Y | Y | Y | Y | N |
| 17f,h | + | PPHP | 38.2 | F | N | 1.82 | N/A | Y | Y | Y | Y | Y | Y | Y | Y | Y |
| 18a | + | PPHP | 39.2 | F | N | 0.64 | N/A | Y | Y | Y | Y | Y | Y | Y | N | N |
| 19g | + | PPHP | 44.8 | F | N | −1.15 | N/A | Y | N | Y | Y | Y | Y | Y | N | N |
| 20c | + | PPHP | 47.8 | F | N | 1.00 | N/A | Y | Y | Y | N | Y | Y | N | N | N |
| 21b | + | PPHP | 47.9 | F | N | 0.78 | N/A | N | Y | N | Y | Y | Y | Y | N | Y |
| 22d | + | PPHP | 56.4 | F | N | 1.02 | N/A | Y | Y | Y | N | N | Y | N | N | Y |
| 23f | − | PHP 1a | 11.1 | F | Y | 1.06 | N/A | Y | N | N | N | N | N | N | N | N |
| 24 | − | PHP 1a | 12.0 | F | N | 2.31 | N/A | Y | N | N | N | U | U | U | U | U |
| 25 | − | PHP 1a | 13.5 | F | P | 1.16 | N/A | Y | N | N | N | N | N | N | N | N |
| 26e | − | PHP 1a | 13.5 | F | P | 2.39 | N/A | Y | N | N | N | N | N | N | N | N |
| 27 | − | PHP 1a | 13.6 | M | Y | 1.05 | N/A | Y | Y | N | N | N | N | N | N | N |
| 28 | − | PHP 1a | 15.0 | F | N | 2.39 | N/A | Y | N | N | N | N | N | N | N | N |
| 29 | − | PHP 1a | 15.4 | M | P | 2.33 | N/A | Y | N | N | N | N | N | N | N | N |
| 30 | − | PHP 1a | 17.0 | F | P | 1.43 | N/A | Y | N | N | N | N | N | N | N | N |
| 31 | − | PHP 1a | 18.0 | M | N | −0.02 | N/A | Y | N | N | N | N | N | N | N | N |
| 32 | − | PHP 1a | 19.7 | M | P | 1.17 | N/A | Y | N | N | N | N | N | N | N | N |
| 33g | − | PHP 1a | 21.7 | F | N | 1.83 | N/A | Y | N | N | Y | N | N | N | N | N |
CTS diagnosis, AHO subtype, age, sex, GH therapy status, BMI Z-score, CTS EMG study result, brachymetacarpia/brachydactyly, and CTS-related symptoms/characteristics (pain, tingling, numbness, bilateral symptoms, flick sign, nocturnal symptoms, fine motor problems, weakness) are listed. Y, Yes; N, no; U, unsure/unknown; N/A, unavailable or not performed; P, previous history of GH treatment; Dx, diagnosis; EMG, electromyogram; F, female; M, male; Sx, symptoms.
a–g
Subjects of the same kindred.
h
Weight for this subject is prior to recent weight gain secondary to pregnancy.