Fig. 2.

Serum sTie2 levels at different stages of pregnancy. A, Tie2 levels in prospectively collected serum samples from subjects who delivered at term with or without preeclampsia. Note that, compared with its levels in controls, sTie2 levels in preeclamptic subjects were significantly (P < 0.05) lower starting at 24–28 wk of gestation and continued to be significantly (P < 0.05) lower through the time of delivery. B, sTie2 levels at delivery in a different cohort of preeclamptic subjects compared with its levels in gestational age-matched controls. Subjects with preeclampsia had significantly lower serum sTie2 levels (P < 0.01).