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HLA-DR3/4 AD patients and general population (DAISY) controls were evaluated for HLA-B allele frequency. Within each bar the number indicates the number of individuals with the given HLA-B allele. HLA-B15 was the only HLA-B allele to be significantly decreased in the AD subjects. Corrected P value for HLA-B15 positivity in HLA-DR3/4 is 2.3 × 10−3.
